The latest meta-analysis from China shows that breast cancer is 44% more likely among Chinese women who have had one or more abortions. Critics claim this study is flawed because it relies on "case-control studies" which match a woman with cancer to a woman without cancer. The "recall bias" theory holds that women with cancer tend to tell the truth about their abortion history, while healthy women tend to conceal their abortions--even in China, where abortion is anything but "a private matter between a woman and her doctor."
It is easy to put the recall bias theory to the test. China has traditionally had a low breast cancer rate (only one out of forty Chinese women expect to get the disease, a mere fraction of the American rate). If abortion does not increase the risk of breast cancer, tens of millions of Chinese abortions should have no impact on cancer incidence in China. But breast cancer in China is rising, and rising rapidly, as this public service simulation from General Electric shows.
This could be mere coincidence. Logicians recognize the post hoc ergo propter hoc fallacy--"after something, therefore because of something." There could be other causes of China's rising cancer rate. Oral contraceptives are known to have carcinogenic effects--but less than 2% of Chinese women have access to the Pill.
Perhaps pollutants are causing the increase. When the pesticide DDT breaks down to DDE, it mimics some of the effects of estrogen, leading some researchers to suspect it as a cause of cancer. China used to use DDT extensively in agriculture. If DDT caused breast cancer, one would expect peasant women in China to have elevated rates, while urban women might be spared. If abortion increases the risk of cancer, the results should be the opposite, because urban women in China are more likely to abort than peasant women are. As it turns out, breast cancer rates are rising more rapidly among urban women in China than among peasants.
Something is causing Chinese breast cancer cases to rise. It isn't the Pill, and it isn't DDT. What, then?
The latest meta-analysis says that women who choose abortion are 44% more likely to get breast cancer than do those that don't. Multiply that small number by millions and you get exactly what China is now experiencing--a rise in breast cancer all over the country with the highest rates in the urban centers.
Showing posts with label oral contraceptives. Show all posts
Showing posts with label oral contraceptives. Show all posts
Sunday, December 8, 2013
Friday, December 6, 2013
Debate the Abortion/Breast Cancer Link
What scientific paper could possibly open up a subject as controversial as "death panels" or "global warming"? How about the latest Chinese research that finds a statistically significant 44% increase in breast cancer risk after induced abortions. For those who are new to the debate, here are the arguments for and against the Abortion/Breast Cancer link.
The link between abortion and breast cancer has been so vigorously and officially denied that many people have decided it simply must be false. Talking about abortion and breast cancer these days is like insisting that Obamacare will create "death panels" or denying global warming.
That's why the new Chinese research matters. It's time for open-minded people to review the arguments and make up their own minds. This page is a place to begin the discussion.
The Argument
- Estrogen is to breast cancer what carbon dioxide is to global warming--with a twist.
- CO2 is a "greenhouse gas" that traps heat, so anthropogenic global-warming ("AGW") theorists argue that the rise in temperatures around the world is the result of humans burning fossil fuels.
- Steroidal estrogen is a recognized carcinogen. Pregnancy loads a woman's body with estrogen, but abortion interrupts the process before other hormones can mature breast tissues. Abortion/breast cancer ("ABC") theorists argue that this can explain the global epidemic of breast cancer since oral contraceptives and abortions became common.
- The twist: people who question the AGW hypothesis are called "deniers" and are told "the science is settled." People who articulate the ABC hypothesis are called "fanatics" and are also told "the science is settled."
Research on Rats
- Pro: Rat breast tissue is more susceptible to mutations in early pregnancy, which raises the risk of cancer. Fortunately, breast tissue becomes specialized in later pregnancy, which reduces the lifetime risk of cancer. Rats that give birth have a lower incidence of cancer, but research shows that interrupted pregnancies confer no protective effect. Although the A/BC link was first hypothesized in 1957, nobody has done a study on rats that is specifically designed to find out whether induced abortions raises the risk of cancer.
- Con: Rats aren't people. The science is settled. We don't need more research.
Research on Pregnancy
- Pro: The age at first live birth is a well-known risk factor for breast cancer. Earlier is better--the sooner a woman has a baby, the lower is her lifetime risk of breast cancer. This is true despite the fact that child-birth itself
raises a woman's risk of breast cancer in the 15 years after birth. This transient risk is due to the impact of estrogen on breast tissue. Abortion leaves a woman with the worst of both worlds--all the elevated risks of pregnancy without the protective effects of birth. - Con: Women don't care about raising their risk of cancer when
they're considering terminating their pregnancy, and doctors shouldn't
tell them about it. It would only confuse and distress them.
Research on Estrogen
- Pro: The suspected link between abortion and breast cancer is based on the high levels of estrogen during pregnancy. Estrogen has been tied to breast cancer time after time. Hormone replacement therapy is a recognized breast cancer risk. Steroidal estrogen is a recognized carcinogen. Injectable contraceptives appear to raise breast cancer risk. Studies on oral contraceptives have been more controversial, but the World Health Organization identifies estrogen-containing oral contraceptives as a "Class 1 carcinogen."
- Con: Only Catholics object to oral contraceptives. This is just another case of religion hiding behind the mask of "science."
Research on Populations
- Pro: Breast cancer is rising around the world, especially in
populations that have begun to use oral contraceptives or induced
abortion. Breast cancer incidence is elevated in every group that tends
to choose abortion: (i.e., young black women, more educated women,
higher status women, etc) and lower in most groups that tend to avoid
abortion (older black women, more religious women, Hispanic women in
Hispanic neighborhoods, etc.). - Con: Claims of a "global epidemic" of breast cancer have been
overblown. Most of the alleged increase in breast cancer in the United
States is simply the result of better publicity and longer lifespans.
Breast Cancer Studies:
Case-Control Studies: Matching women with breast cancer to otherwise-identical women
- Pro: Study after study finds a modest increase in breast cancer risk. The studies that distinguish women who had abortions from women who took the Pill are consistent with an increase in risk of 3% per week of terminated pregnancy. Studies designed to correct for the possibility of "recall bias" fail to find any.
- Con: Any apparent increase can be explained by "recall bias," which holds that women who get sick tell the truth while women who are healthy tend to maintain their privacy.
Cohort Studies: Following large groups of previously-identified women over time
- Pro: Cohort studies, which track large groups of women over
time, necessarily fail to address the multiple variables that affect
breast cancer risk. Studies funded by big drug companies should be
scrutinized as carefully as studies by tobacco companies. - Con: Cohort studies are the most reliable because they are the largest and are not subject to recall bias.
Recall Bias: Do Healthy Women Conceal Abortions?
- Pro: Janet Daling, of Seattle's Fred Hutchinson Cancer Research Institute, is personally pro-choice but is even more anti-cancer. Her research on the abortion/breast cancer link was elegantly designed to detect any evidence of recall bias. She included three groups of women in her study: some with breast cancer, some with cervical cancer, and some who were healthy. The recall bias theory suggests that women with cancer (whether breast cancer or cervical cancer) would tell the truth, while healthy women might be shy. She found no evidence of an increase in risk among women with cervical cancer, but a statistically significant increase among women who chose abortion.
- Con: Recall bias explains all the apparent increase in risk.
Hypothesis Or Theory?
- Pro: Before the National Institute of Health convened its panel to discuss this issue in 2003, almost every paper on the topic concluded with "more research is needed." The research done since then is consistent with a modest, transient increase in breast cancer risk after induced abortion as long as one recognizes the confounding effect of oral contraceptives. With the latest meta-analysis from China, it's time to stop calling this the "abortion/breast cancer hypothesis" and recognize it as a valid scientific theory.
- Con: The hypothesis has been disproved. The science is settled. The continuing obsession about this is just more right-wing, anti-choice obfuscation.
Conclusion
The link between abortion and breast cancer has been so vigorously and officially denied that many people have decided it simply must be false. Talking about abortion and breast cancer these days is like insisting that Obamacare will create "death panels" or denying global warming.
That's why the new Chinese research matters. It's time for open-minded people to review the arguments and make up their own minds. This page is a place to begin the discussion.
Thursday, December 5, 2013
Chinese Abortions and American Health
In 1981, Dr. Malcolm Pike studied 163 Los Angeles breast cancer patients under the age of 33 and found that women who had used oral contraceptives were significantly more likely to get breast cancer than women who did not. The "relative risk" for women who had taken the Pill for six years of more was 2.2--which means they were twice as likely to get breast cancer as were women who did not take the Pill... with one exception. Women who had abortions (instead of relying on oral contraceptives) were even more likely to get breast cancer.
Pike did not zero in on abortions and the Pill because he disapproved of them on religious grounds, but because both of them expose a woman to estrogen. Estrogen has a well-documented impact on breast cancer risk. The Pill artificially adds estrogen to a woman from the outside, while pregnancy adds estrogen from the inside. Estrogen raises the risk of breast cancer in the 15 years after a normal birth, but the final stages of pregnancy mature the breast tissue so much that the overall effect of childbirth is to lower a woman's lifetime risk. Abortion leaves women with all the elevated risks of early pregnancy and none of the protective effects of third-trimester maturation.
The women in Pike's study were all under 32 when they got cancer. That's how many years have passed since Pike first published his findings. What has happened since then? Wikipedia lists 113 references on its "abortion/breast cancer hypothesis" page, and many of them show an elevated risk after abortion. The elevated risk is small, as these things go--a transient increase in risk of about 3% per week of terminated pregnancy. It takes a big study to turn something that small into a significant finding, and most of the big studies have been funded by big organizations, such as governments and/or pharmaceutical companies.
To date, none of the studies funded by drug companies separate women who take oral contraceptives from women who have abortions. Imagine a tobacco company comparing lung cancer risks among pipe smokers to non-pipe-smokers without ever asking about cigarettes. That's what you get when a drug company simplistically compares women who terminated their pregnancy to women who avoided pregnancy... somehow. You have to ask about the Pill!
Not all studies have been funded by big drug companies, however, resulting in a steady drip of studies with elevated breast cancer risks after abortion. How can scientists ignore this? The answer is something called "recall bias." Abortion is such a private matter that healthy woman don't usually want to disclose it. All that changes when a woman gets cancer, however. If all the healthy women "forget" their abortions and all the sick women remember them, it would look like sick women had had more abortions even if they didn't really.
Between small numbers, recall bias, oral contraceptives, and the red-hot politics of abortion, all this can be confusing. Reasonable scientists have been able to disagree about the abortion/cancer link, and, as a result, American women have been choosing abortion for the last 32 years without finding out about this issue. But the latest research from China clears away the confusion.
Time Magazine reports that only 1.2% of Chinese women take the Pill, resulting in a lot of pregnancies. With China's "one-child per couple" policy, that has led to 13 million abortions every year. Unlike America, where these abortions are a "private matter between a woman and her doctor," Chinese data on abortions are kept by the same government agencies that conduct the procedures. With such huge numbers, official government data, and virtually no oral contraceptives, Chinese research on the abortion/breast cancer link should be as solid as research on living human beings can ever ethically be.
And the latest research devastates the claim that there is no link between abortion and breast cancer. The newest study from China perfectly matches the evidence from earlier studies suggesting that each week of a terminated pregnancy raises a woman's transient risk by approximately 3%. For a single abortion at 15-weeks, one would expect a 45% increase in risk. The meta-analysis reports a 44% rise. A second abortion would add more exposure, adding more risk. Two abortions in China leads to a 76% increase in risk. A third abortion would raise the risk even more--and Chinese women with three abortion had an average increased risk of 89%. This kind of "dose-response relationship" is very persuasive to open-minded researchers... especially when the "dose" is something with such a clear-cut relationship to breast cancer as estrogen.
Do you think this is going to change any medical minds? It will--but not in America any time soon. But that no longer matters. China has too many women and too many scientists to wait around for American "researchers" any longer.
Pike did not zero in on abortions and the Pill because he disapproved of them on religious grounds, but because both of them expose a woman to estrogen. Estrogen has a well-documented impact on breast cancer risk. The Pill artificially adds estrogen to a woman from the outside, while pregnancy adds estrogen from the inside. Estrogen raises the risk of breast cancer in the 15 years after a normal birth, but the final stages of pregnancy mature the breast tissue so much that the overall effect of childbirth is to lower a woman's lifetime risk. Abortion leaves women with all the elevated risks of early pregnancy and none of the protective effects of third-trimester maturation.
The women in Pike's study were all under 32 when they got cancer. That's how many years have passed since Pike first published his findings. What has happened since then? Wikipedia lists 113 references on its "abortion/breast cancer hypothesis" page, and many of them show an elevated risk after abortion. The elevated risk is small, as these things go--a transient increase in risk of about 3% per week of terminated pregnancy. It takes a big study to turn something that small into a significant finding, and most of the big studies have been funded by big organizations, such as governments and/or pharmaceutical companies.
To date, none of the studies funded by drug companies separate women who take oral contraceptives from women who have abortions. Imagine a tobacco company comparing lung cancer risks among pipe smokers to non-pipe-smokers without ever asking about cigarettes. That's what you get when a drug company simplistically compares women who terminated their pregnancy to women who avoided pregnancy... somehow. You have to ask about the Pill!
Not all studies have been funded by big drug companies, however, resulting in a steady drip of studies with elevated breast cancer risks after abortion. How can scientists ignore this? The answer is something called "recall bias." Abortion is such a private matter that healthy woman don't usually want to disclose it. All that changes when a woman gets cancer, however. If all the healthy women "forget" their abortions and all the sick women remember them, it would look like sick women had had more abortions even if they didn't really.
Between small numbers, recall bias, oral contraceptives, and the red-hot politics of abortion, all this can be confusing. Reasonable scientists have been able to disagree about the abortion/cancer link, and, as a result, American women have been choosing abortion for the last 32 years without finding out about this issue. But the latest research from China clears away the confusion.
Time Magazine reports that only 1.2% of Chinese women take the Pill, resulting in a lot of pregnancies. With China's "one-child per couple" policy, that has led to 13 million abortions every year. Unlike America, where these abortions are a "private matter between a woman and her doctor," Chinese data on abortions are kept by the same government agencies that conduct the procedures. With such huge numbers, official government data, and virtually no oral contraceptives, Chinese research on the abortion/breast cancer link should be as solid as research on living human beings can ever ethically be.
And the latest research devastates the claim that there is no link between abortion and breast cancer. The newest study from China perfectly matches the evidence from earlier studies suggesting that each week of a terminated pregnancy raises a woman's transient risk by approximately 3%. For a single abortion at 15-weeks, one would expect a 45% increase in risk. The meta-analysis reports a 44% rise. A second abortion would add more exposure, adding more risk. Two abortions in China leads to a 76% increase in risk. A third abortion would raise the risk even more--and Chinese women with three abortion had an average increased risk of 89%. This kind of "dose-response relationship" is very persuasive to open-minded researchers... especially when the "dose" is something with such a clear-cut relationship to breast cancer as estrogen.
Do you think this is going to change any medical minds? It will--but not in America any time soon. But that no longer matters. China has too many women and too many scientists to wait around for American "researchers" any longer.
Tuesday, December 3, 2013
Oral Contraceptives and Cancer
The National Cancer Institute admits there is some evidence that women who use oral contraceptives face an increased risk of breast cancer for several years. That is no surprise, since the Pill delivers estrogen to a woman's body, and increased exposure to estrogen is associated with elevated breast cancer risk. The mystery is not that oral contraceptives raise breast cancer risk, but that they don't appear to raise the risk anywhere near enough to account for the global epidemic of breast cancer since they became widely available in the 1960s.
What the National Cancer Institute won't tell you is that oral contraceptives are just one way a woman can get an abnormal exposure to estrogen. Pregnancy also delivers "sudden and dramatic increases in estrogen." There's nothing abnormal about pregnancy, of course, but doctors are well aware of a "transient" increase in breast cancer risk after birth. A full-term pregnancy matures and specializes breast tissue, reducing a woman's lifetime risk of breast cancer--but only after an elevated risk for the fifteen years after birth.
If a full-term pregnancy raises risk in the short term but lowers risk overall, what about an interrupted pregnancy? Miscarriages, which are often associated with insufficient estrogen levels, don't seem to have a measurable effect on breast cancer risk, but interrupting a viable pregnancy seems to produce the worst of both worlds--elevated short-term risk (due to estrogen) without the long-term benefit of mature, milk-producing tissue. In other words, it would seem that abortion must increase the risk of breast cancer in young women.
How come you don't hear that from the National Cancer Institute? The reason may disturb you. Study after study has been published on the abortion/breast cancer link, with varying results. Some, such as the most recent meta-analyis from China, find an elevated risk of cancer after abortion.
Others find no increase in risk--but those studies simply compare women who have abortions to women who don't have abortions. That's like comparing pipe smokers to non-pipe-smokers instead of comparing pipe smokers to cigarette smokers to non-smokers. If estrogen is what elevates the risk of breast cancer, it makes no sense to compare one group of women with elevated estrogen levels (pill takers) to another group of women with elevated estrogen levels (whose pregnancies were terminated by induced abortions).
Once you include all sources of elevated estrogen, the "global epidemic" of breast cancer suddenly makes sense. Breast cancer is on the rise among all groups that routinely use oral contraceptives or choose abortion, while it tends to remain at normal levels among women without an artificially high exposure to estrogen.
If this is true, why isn't everybody talking about it? First of all, in our ultra-politicized world, anybody who mentions the abortion/breast cancer link is instantly marginalized--just like Sarah Palin was when she claimed Obamacare would lead to death panels. (If you haven't noticed, the mainstream media finally admits that death panels are real.) Second, many of the biggest (and most questionable) studies on abortion and breast cancer have been funded by the same drug companies that produce the Pill. And finally, the political and legal implications of an abortion/breast cancer link are overwhelming. At a minimum, Planned Parenthood would be bankrupted by malpractice suits, and Roe v. Wade itself would have to be reconsidered in light of a genuine medical danger. The stakes in America are too high to let science be science.
But that can't be all there is to it! Science is science, and even the tobacco industry had to hide the evidence that smoking led to cancer. How can drug companies hide the evidence of an abortion/breast cancer link? The answer is, they don't. They just attribute it to "recall bias," arguing that women who choose abortion tend to be ashamed of their choice, and so don't tell the truth about their own medical history until they get cancer--at which point, life trumps privacy. With this approach, study after study that shows an elevated risk can be ignored every time. Without direct experiments on living human beings (which violates every principle of medical ethics), indirect evidence of increased risk gets ignored time after time.
Except in China. Abortion there has none of the personal stigma that it has in the United States, and medical records on abortions are easily available. With nearly a billion people and a state-mandated one-child per couple policy, China is the next best thing to a laboratory for conducting direct experimentation on living human beings. This makes it especially significant that Chinese researchers are pointing out the consistent elevated risk after abortion.
Convinced? Then tell a friend--or ten. Forward this link to folks who need to know.
Skeptical? I haven't scratched the surface of the evidence for this link. Post your questions or critiques in the comment section below and I'll respond to them as time permits.
Angry? That's what the comments are for--but please keep it clean, or I'll delete it, whether you're roasting me or toasting me. This blog is intended for the whole family, with a zero tolerance policy on profanity.
What the National Cancer Institute won't tell you is that oral contraceptives are just one way a woman can get an abnormal exposure to estrogen. Pregnancy also delivers "sudden and dramatic increases in estrogen." There's nothing abnormal about pregnancy, of course, but doctors are well aware of a "transient" increase in breast cancer risk after birth. A full-term pregnancy matures and specializes breast tissue, reducing a woman's lifetime risk of breast cancer--but only after an elevated risk for the fifteen years after birth.
If a full-term pregnancy raises risk in the short term but lowers risk overall, what about an interrupted pregnancy? Miscarriages, which are often associated with insufficient estrogen levels, don't seem to have a measurable effect on breast cancer risk, but interrupting a viable pregnancy seems to produce the worst of both worlds--elevated short-term risk (due to estrogen) without the long-term benefit of mature, milk-producing tissue. In other words, it would seem that abortion must increase the risk of breast cancer in young women.
How come you don't hear that from the National Cancer Institute? The reason may disturb you. Study after study has been published on the abortion/breast cancer link, with varying results. Some, such as the most recent meta-analyis from China, find an elevated risk of cancer after abortion.
A systematic review and meta-analysis of 36 Chinese studies by Dr. Yubei Huang and his colleagues in the prestigious journal, Cancer Causes Control, last week reported a significant 44% increased breast cancer risk among women with at least one induced abortion...
Others find no increase in risk--but those studies simply compare women who have abortions to women who don't have abortions. That's like comparing pipe smokers to non-pipe-smokers instead of comparing pipe smokers to cigarette smokers to non-smokers. If estrogen is what elevates the risk of breast cancer, it makes no sense to compare one group of women with elevated estrogen levels (pill takers) to another group of women with elevated estrogen levels (whose pregnancies were terminated by induced abortions).
Once you include all sources of elevated estrogen, the "global epidemic" of breast cancer suddenly makes sense. Breast cancer is on the rise among all groups that routinely use oral contraceptives or choose abortion, while it tends to remain at normal levels among women without an artificially high exposure to estrogen.
If this is true, why isn't everybody talking about it? First of all, in our ultra-politicized world, anybody who mentions the abortion/breast cancer link is instantly marginalized--just like Sarah Palin was when she claimed Obamacare would lead to death panels. (If you haven't noticed, the mainstream media finally admits that death panels are real.) Second, many of the biggest (and most questionable) studies on abortion and breast cancer have been funded by the same drug companies that produce the Pill. And finally, the political and legal implications of an abortion/breast cancer link are overwhelming. At a minimum, Planned Parenthood would be bankrupted by malpractice suits, and Roe v. Wade itself would have to be reconsidered in light of a genuine medical danger. The stakes in America are too high to let science be science.
But that can't be all there is to it! Science is science, and even the tobacco industry had to hide the evidence that smoking led to cancer. How can drug companies hide the evidence of an abortion/breast cancer link? The answer is, they don't. They just attribute it to "recall bias," arguing that women who choose abortion tend to be ashamed of their choice, and so don't tell the truth about their own medical history until they get cancer--at which point, life trumps privacy. With this approach, study after study that shows an elevated risk can be ignored every time. Without direct experiments on living human beings (which violates every principle of medical ethics), indirect evidence of increased risk gets ignored time after time.
Except in China. Abortion there has none of the personal stigma that it has in the United States, and medical records on abortions are easily available. With nearly a billion people and a state-mandated one-child per couple policy, China is the next best thing to a laboratory for conducting direct experimentation on living human beings. This makes it especially significant that Chinese researchers are pointing out the consistent elevated risk after abortion.
Convinced? Then tell a friend--or ten. Forward this link to folks who need to know.
Skeptical? I haven't scratched the surface of the evidence for this link. Post your questions or critiques in the comment section below and I'll respond to them as time permits.
Angry? That's what the comments are for--but please keep it clean, or I'll delete it, whether you're roasting me or toasting me. This blog is intended for the whole family, with a zero tolerance policy on profanity.
Contempt for Catholics
Cardinal Timothy Dolan, the archbishop of New York, says the Catholic church finds itself opposed to ObamaCare. This isn't how Roman Catholic bishops wanted this to go. According to Fox News, Cardinal Dolan directed his remarks to President Obama, saying:
Our government has begun negotiating with Iran's ayatollahs. Wouldn't it be worth their time to spend a little more effort on the bishops?
We want to be with you. We want to be strong, and if you keep doing this, we’re not going to be able to be one of your cheerleaders.Catholic leaders want health care for every person in America, from the baby in the womb to the stranger in our midst. Obamacare doesn't cover unborn babies or illegal immigrants. Instead, it mandates oral contraceptives, which do nothing to prevent conception, but instead flush each fertilized embryo from the womb.
Our government has begun negotiating with Iran's ayatollahs. Wouldn't it be worth their time to spend a little more effort on the bishops?
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